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International Team of Researchers Find Herbal Extract to be Effective In Preventing Migraine - An herbal extract offers considerable help in preventing migraine headaches, according to an international research team led by Dr. Richard B. Lipton of the Albert Einstein College of Medicine of Yeshiva University. The extract comes from the petasites hybridus root （also known as butterbur）, which has been used for medicinal purposes since ancient times. The researchers reported their findings in the December 28th issue of the journal Neurology.
“Butterbur is a traditional herbal treatment for migraine prevention,” says Dr. Lipton, who is vice chair and professor of neurology at Einstein. “Our study shows that butterbur really does reduce the frequency of migraine attacks, so it's a welcome addition to the therapeutic arsenal we have available to combat migraine.”
The study involved 245 migraine patients who--during the prior three months-- suffered between two to six migraine attacks per month. For the four-month study, the patients were randomly assigned to take two capsules daily of the 75 milligram （mg） dose of butterbur extract, the 50-mg dose, or a placebo. The main outcome measured was the percentage decrease in the frequency of migraine attacks, calculated by comparing migraine attacks during the study with the number of attacks that patients experienced before the study began.
“The 75-mg butterbur dose reduced headache frequency by 48 percent - a substantial treatment effect,” said Dr. Lipton. This compared with a 26 percent reduction among placebo users. Further, Dr. Lipton notes, the 75-mg dose reduced headache frequency by 50% or more in over two-thirds of the migraine sufferers.
The study was conducted at nine primary care or specialty centers in the United States and Germany. Adverse effects from butterbur were infrequent; those most commonly reported that may have been related to butterbur treatment were gastrointestinal in nature, mainly burping.
Raw butterbur root contains toxic chemicals that are filtered out during the manufacturing process - a good reason, says Dr. Lipton, for avoiding “home-brewed” butterbur extract and instead using commercially available products, several of which are sold in the U.S. He further stressed that manufacturing standards are not uniform for plant extracts and that safety data for Petadolex, the brand used in this study, cannot be assumed for other butterbur products. Petadolex is made by Weber & Weber GmbH & Co., which supported the research. |
由理查得·B·利普顿领导的一个国际科研小组表示，款冬类草药提取物对防治偏头痛极有帮助。款冬早在古代时就被用于医疗。
根据这个小组的发现，款冬确实可以减少偏头痛的发作。
这次研究共有245位偏头痛患者参加，这些病人偏头痛发作次数在每月2－6次之间。在为期4个月的研究中，他们随意指定病人每天服用两种胶囊，75/50毫克的款冬提取胶囊和安慰剂。与研究前相比，病人偏头痛发作次数成百分比下降。75毫克款冬使偏头痛减少了48%，而服用安慰剂的病人的偏头痛发作次数减少26%。而且，在2/3以上偏头痛患者中，75毫克剂型的可将头痛次数减少50%以上。
这次研究晨美国和德国进行的，其最常见的副作用主要是嗳气。
原始款冬根含有毒性物质，这种毒性物质在制作时已经滤除。目前这种药物已经在美国进行销售，其商标为“Petadolex”，由支持这项研究的Weber & Weber GmbH & Co.生产。 |
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